Correlation Between Atherosclerotic Carotid Plaque Composition and the Neuropathological Lesions of Alzheimer’s Disease: Partial Results
Given that the fibrous cap is typically present in advanced atherosclerosis, and considering that smooth muscle cell area was solely assessed in the absence of well-established atherosclerotic plaque, our examination of atherosclerotic plaque composition in carotid artery segments suggests a connection between atherosclerosis development and the accumulation of neurofibrillary tangles in the brain. We found an association with the fibrous cap proportion of the tunica intima area and an inverse association with the proportion of smooth muscle cells in the tunica intima area.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Alberto Fernando Oliveira Justo (ORCID: https://orcid.org/0000-0001-5531-0485)
- Carlos Augusto Pasqualucci (ORCID: https://orcid.org/0000-0001-6608-2473)
- M. Braga (ORCID: https://orcid.org/0000-0001-8109-1001)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Ricardo Nitríni (ORCID: https://orcid.org/0000-0002-5721-1525)
- Pilar Barbosa (ORCID: https://orcid.org/0000-0001-5241-9637)
- Daniela Souza Farias‐Itao (ORCID: https://orcid.org/0000-0001-6297-751X)
- Wilson Jacob Filho (ORCID: https://orcid.org/0000-0003-2290-4492)
- Beatriz Pontes
Institutions
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085964
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00