Identifying the regulatory cascade governing amyloid precursor protein macropinocytosis and subsequent production of amyloid‐beta

These results demonstrate the sequential recruitment of regulatory proteins which regulate macropinocytosis of APP in response to its crosslinking. Fe65 and Arf6 are rapidly recruited to APP, followed by sustained recruitment of Rac1, RhoA and Cdc42. These regulatory proteins could be targeted to modulate APP-lysosomal trafficking and reduce Aβ production.