Clinical criteria for a limbic‐predominant amnestic neurodegenerative syndrome highly associated with TDP‐43 and slow clinical progression
The implementation of LANS criteria has implications for disambiguating the different driving etiologies of progressive amnestic presentations in older age to guide prognosis, treatment, and clinical trial design and enrollment. The development of in vivo biomarkers specific to TDP-43 pathology are needed to further refine molecular associations between LANS and LATE-NC and precise antemortem diagnoses of LATE.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Nikki H. Stricker (ORCID: https://orcid.org/0000-0001-9034-1252)
- Michel J. Grothe (ORCID: https://orcid.org/0000-0003-2600-9022)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Nick Corriveau‐Lecavalier (ORCID: https://orcid.org/0000-0002-6561-9870)
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Vijay K. Ramanan (ORCID: https://orcid.org/0000-0001-6591-8734)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Hugo Botha (ORCID: https://orcid.org/0000-0003-4390-685X)
- Stuart J. McCarter (ORCID: https://orcid.org/0000-0001-8158-8835)
- Aivi T. Nguyen (ORCID: https://orcid.org/0000-0003-1809-9451)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Aaron Switzer (ORCID: https://orcid.org/0009-0005-2312-9303)
- Ross R. Reichard
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
Institutions
- Mayo Clinic (US)
- University of Kentucky (US)
- German Center for Neurodegenerative Diseases (DE)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084087
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00