Selective Vulnerability of hippocampi for inducible nitric oxide synthase and 3‐nitrotyrosine in Alzheimer’s disease: A Postmortem Study
CA3 neurons shows a particular susceptibility to accumulate iNOS and 3-NT during AD progression. The association between iNOS and functional cognition underscore the role of oxidative stress in AD pathogenesis. Of note, CA2 sector, a resistant region to AD showed no signs of oxidative stress in AD.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Alberto Fernando Oliveira Justo (ORCID: https://orcid.org/0000-0001-5531-0485)
- Carlos Augusto Pasqualucci (ORCID: https://orcid.org/0000-0001-6608-2473)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Ricardo Nitríni (ORCID: https://orcid.org/0000-0002-5721-1525)
- Eliana Cristina de Brito Toscano (ORCID: https://orcid.org/0000-0002-8756-0689)
- Wilson Jacob Filho (ORCID: https://orcid.org/0000-0003-2290-4492)
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085961
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00