Multi‐day at‐home assessments of speech acoustics in Dutch cognitively normal adults with‐and without AD pathology
Our results demonstrated that Aβ-pathology was associated with more pauses during free speech in cognitively healthy adults. This supports the notion that remote multi-day speech assessments have the potential to monitor cognitive changes, for example in observational studies and decentralized clinical trials in preclinical AD. Next steps include examining the association between Aβ-pathology and linguistic features using the same sample.
Authors
- Lyduine E. Collij (ORCID: https://orcid.org/0000-0001-6263-1762)
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- Mark A. Dubbelman (ORCID: https://orcid.org/0000-0002-5708-4925)
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- William Simpson (ORCID: https://orcid.org/0000-0003-1671-5660)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Jessica Robin (ORCID: https://orcid.org/0000-0003-4153-2655)
- Casper de Boer
- Marissa D. Zwan (ORCID: https://orcid.org/0000-0003-0879-2164)
- Rosanne L. van den Berg (ORCID: https://orcid.org/0009-0008-0685-9074)
- Lisa‐Marie Schlüter
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087304
- Primary Topic
- Voice and Speech Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00