Amylin vasculopathy impairs cerebral Aβ efflux through altering cerebral vasodilation
Our results indicate perivascular Aβ deposits in the setting of AD are potentially linked to amylin vasculopathy and altered spontaneous contraction/relaxation of cerebrovascular SMCs. Future experiments will focus on delineating molecular markers of amylin-induced alterations of SMC contractile phenotype.
Authors
- Florin Despa (ORCID: https://orcid.org/0000-0002-5879-6449)
- Ravichandra Shivalingappa Davargaon (ORCID: https://orcid.org/0000-0001-5526-8037)
- Noah Leibold (ORCID: https://orcid.org/0000-0001-7737-0382)
- Nirmal Verma (ORCID: https://orcid.org/0000-0002-9218-2475)
- David K. Powell
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093349
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00