sTREM2 mediates the correlation between BIN1 gene polymorphism and tau pathology in Alzheimer’s disease
This study demonstrated correlation between BIN1 loci and CSF AD biomarkers as well as microglia biomarker, particularly in preclinical AD. Additionally, the link between BIN1 loci and AD pathology was partially mediated by CSF sTREM2.
Authors
- Zuo‐Teng Wang
- Lan Tan (ORCID: https://orcid.org/0000-0002-8759-7588)
- Tao Shan (ORCID: https://orcid.org/0000-0001-6680-9302)
- Zehu Sheng
- Qing‐Fei Zhao
- Fan Guo (ORCID: https://orcid.org/0000-0001-6417-3566)
- Ya‐Nan Ou
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087956
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00