Molecular and functional analysis using Presenilin‐1 G206A mutation iPSC lines to understand age‐of‐onset variability in autosomal dominant Alzheimer disease

Our iPSC lines will be instrumental to identify potential molecular determinants of AOO in PSEN1 mutation carriers. Transcriptomic and functional data is in process and will be presented at the conference. These data will be informative for the identification of molecular changes associated with PSEN1 mutations in neurons and other cell types that will further increase our understanding of PSEN1 role in AD pathogenesis.