Spatial Transcriptomics Analysis Identifies Glial Signatures Spatially Associated with Neuritic Plaques in Human Post‐Mortem Brains
Here, we demonstrate the heterogeneity in glial communities within the amyloid plaque microenvironment. We show evidence suggesting a spatial enrichment of SERPINA3<sup>+</sup> astrocytes at neuritic plaques. Furthermore, the identification of the 182 plaque-proximal genes suggests involvement of processes related to inflammation, and ion transport and homeostasis. The role of these subtypes and molecular signatures in AD pathophysiology remains to be elucidated.
Authors
- Alexandra Kroshilina
- Berke Karaahmet (ORCID: https://orcid.org/0000-0003-2228-4967)
- Mariko Taga (ORCID: https://orcid.org/0000-0003-3780-7054)
- Christina Yung
- Hans‐Ulrich Klein (ORCID: https://orcid.org/0000-0002-6382-9428)
- Ya Zhang (ORCID: https://orcid.org/0000-0002-2158-0660)
- A. B. Sigalov
- Laurine Duquesne
Institutions
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087498
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00