Gut microbiome phytoestrogen production and its protective role in Alzheimer’s disease

Adlercreutzia equolifaciens and similar phytoestrogen-metabolizing bacteria may protect the intestinal epithelium against bacterial invasion and subsequent systemic inflammation, thereby preventing cognitive decline. Our continuing work aims to further establish the connection between AD related neurocognitive decline, the microbiome, and immune system. A. equolifaciens is therefore a strong candidate as a microbiome-based therapeutic acting along the gut-brain axis in AD.