Differential alterations of lateral entorhinal cortex impact on CA1 pyramidal neuron subpopulations in PS19 mouse model of tauopathy
LEC drive of CA1 PNs exhibits a cell type-specific vulnerability to tauopathy, with sPNs differentially susceptible to a reduction of excitation, without changes in feedforward inhibition. Our results further support a postsynaptic mechanism that may be due to spine loss, changes in spine morphology, or shifts in glutamate receptor expression.
Authors
- Arjun V. Masurkar (ORCID: https://orcid.org/0000-0002-2498-2059)
- Thangavel Mohankumar (ORCID: https://orcid.org/0000-0002-2737-9087)
- Isabel Reyes
- Chengju Tian
Institutions
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087085
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00