Sequential neuroanatomical pattern of TAR DNA‐binding protein 43 type C propagation using imaging and pathological findings
Our results highlighted the potential trajectory of TDP-type C pathology over the disease course which likely originates in the ATL and extends posteriorly and inferiorly to affect the ITG and parahippocampal regions. The progression pattern suggests that sensorimotor centers and the angular gyrus, as well as the regions associated with primary visual processing, tend to be compromised in the later stages of the disease based on both imaging and neuropathological findings.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Hülya Ulugut (ORCID: https://orcid.org/0000-0002-5016-2505)
- Jessica Deleon (ORCID: https://orcid.org/0000-0002-9779-0541)
- Maria Luisa Gorno‐Tempini (ORCID: https://orcid.org/0000-0002-7426-7782)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Zachary Miller (ORCID: https://orcid.org/0000-0002-5991-3053)
- Maria Luisa Mandelli (ORCID: https://orcid.org/0000-0002-2518-2520)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
- Eric Lang (ORCID: https://orcid.org/0000-0001-5136-1875)
- Diego L. Lorca‐Puls (ORCID: https://orcid.org/0009-0004-4534-1834)
- Golnaz Yadollahikhales (ORCID: https://orcid.org/0000-0002-3377-9431)
- Janhavi Pillai
Institutions
- Cedars-Sinai Medical Center (US)
- University of Concepción (CL)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093527
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 0.00