Phenotypic characterization of a novel <i>Spi1*rs1377416</i> mouse model of Alzheimer’s Disease
Our results indicate that the rs1377416 variant of SPI1 induces an age-dependent increase in amyloid deposition in the 5xFAD model of AD. Moreover, this SPI1 variant exerts a protective effect by suppressing astrocytic response and preventing neuritic and axonal damage. There is a strong sex difference observed between males and females when the variant is present and requires further investigation.
Authors
- Frank M. LaFerla (ORCID: https://orcid.org/0000-0003-2324-6911)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)
- Giedre Milinkeviciute (ORCID: https://orcid.org/0000-0003-2527-3892)
- Celia Da Cunha
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Claire A. Butler (ORCID: https://orcid.org/0000-0001-9320-8297)
- Adrian Mendoza‐Arvilla (ORCID: https://orcid.org/0000-0002-9076-1983)
- Jonathan Neumann
- Amber Walker
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090451
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00