Advancements in High‐Resolution MRI Postmortem brain imaging: Histological examination on cells exclusively exhibiting White Matter Hyperintensities made possible using a novel, 3D printed, reusable, imaging container and cutting guide
This innovative combination of the cutting guide, container, and the custom 7T TTT coil is reusable and reliable. It accommodates various brain sizes, offers precise cutting options, ensures fast and accurate image registration to in vivo and gross anatomy, and achieves homogeneous B1 fields, culminating in superior research data. The described method is subject to ongoing refinement for enhanced efficiency, with iterative optimization of the container's shape, size, and function through 3D printing. This work was supported by the National Institutes of Health under award numbers R01MH111265, R01AG063525, T32MH119168, and U19AG068054.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Joseph Mettenburg
- Jinghang Li (ORCID: https://orcid.org/0000-0003-1960-9839)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Jr‐Jiun Liou (ORCID: https://orcid.org/0000-0002-8800-9557)
- Tamer S. Ibrahim (ORCID: https://orcid.org/0000-0001-6738-5855)
- Tales Santini (ORCID: https://orcid.org/0000-0003-4533-9190)
- Andrea Sajewski (ORCID: https://orcid.org/0000-0002-5978-268X)
- Jacob Berardinelli (ORCID: https://orcid.org/0009-0007-3428-4821)
- Minjie Wu (ORCID: https://orcid.org/0000-0002-8978-3851)
- Nadim Farhat (ORCID: https://orcid.org/0000-0002-6443-9165)
Institutions
- University of Pittsburgh (US)
- UPMC Health System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093523
- Citations
- 2
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health