Functional assessment of Phospholipase D1 using wild‐type, transgenic AD mice, and human spheroid models: A spatial and temporal mechanism for the progression of neurodegeneration
Our research provides a novel insight into how PLD1 contributes to progressive functional deficits associated with synaptic dysfunction by impinging on critical cellular signaling events compromised in early and late stages of Alzheimer's disease.
Authors
- Marc Ferrer (ORCID: https://orcid.org/0000-0003-4569-9137)
- Emily Lee
- Joshua D. Currie (ORCID: https://orcid.org/0000-0001-7402-4265)
- Sahana Murthy (ORCID: https://orcid.org/0000-0001-9281-3604)
- Chandramouli Natarajan
- Jiajing Zhang (ORCID: https://orcid.org/0000-0002-5222-372X)
- Thomas A. Green (ORCID: https://orcid.org/0000-0002-7244-0991)
- Balaji Krishnan (ORCID: https://orcid.org/0000-0003-2074-4165)
- Poonam Shah (ORCID: https://orcid.org/0000-0001-5679-9702)
- Shalini Mohanty (ORCID: https://orcid.org/0000-0002-0424-792X)
- Enoch Wong
- Agenor Limón (ORCID: https://orcid.org/0000-0002-6613-770X)
- Shaneilahi Budhwani
- Klarissa H Garza
- Malav Mallipudi
- Marc Juárez
- Sarah Bosworth
- Kyle S Sheth
Institutions
- National Center for Advancing Translational Sciences (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089269
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00