Organizing Alzheimer’s Disease Endophenotypes Into Subdivisions of Biological Domains Improves Therapeutic Target Hypothesis Selection
A layered knowledge approach of investigating the impact a gene has on an endophenotype provides insight into how a potential therapeutic target would interact with other areas of disease biology. TREAT-AD investigators will validate these targets in cell models and generate experimental resources to support further target development.
Authors
- Robert R. Butler (ORCID: https://orcid.org/0000-0003-0200-8682)
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Karina Leal
- Jesse C. Wiley (ORCID: https://orcid.org/0000-0002-1430-772X)
- Gregory A. Cary (ORCID: https://orcid.org/0000-0003-3573-5229)
- Stephen Keegan (ORCID: https://orcid.org/0000-0002-0439-4727)
- Anna Greenwood (ORCID: https://orcid.org/0000-0003-0605-431X)
Institutions
- Sage Bionetworks (US)
- Jackson Laboratory (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092649
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00