Genetically predicted levels of sex hormones are associated with cerebrovascular disease pathology in the Alzheimer’s disease brain
The results show that a PRS of sex hormones can be used to explore the effect of sex hormone levels on cerebrovascular pathology as it pertains to AD. The results also support the need for more studies investigating the role of sex hormones on sex-specific phenotypes of cerebrovascular pathology in the presence of AD. Future work is needed to better understand the mechanisms behind the observed associations.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Sarah Biber
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- C. Dirk Keene (ORCID: https://orcid.org/0000-0002-5291-1469)
- Kathleen S. Montine (ORCID: https://orcid.org/0000-0003-2110-8363)
- Eric B. Larson (ORCID: https://orcid.org/0000-0003-4782-5360)
- Julia B. Libby
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Shubhabrata Mukherjee (ORCID: https://orcid.org/0000-0003-2522-2884)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Paul K. Crane (ORCID: https://orcid.org/0000-0002-7327-3873)
- Matthew S. Panizzon (ORCID: https://orcid.org/0000-0002-6449-2097)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0003-1454-8643)
- David A. Bennett
Institutions
- Broad Institute (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- University of Miami (US)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- University of California San Diego (US)
- Dr. John T. Macdonald Foundation (US)
- Rush University (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092453
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00