Altered Hepatic and Cerebral Lipid Mediator Pathways in Alzheimer’s Disease
Our data show significant alterations in lipid mediators in both the AD brain and liver, with liver exhibiting the most pronounced changes. This supports AD being a systemic disorder with the potential for liver to regulate brain function via lipid mediators and emphasizes the complexity of lipid metabolism in AD. Sex distinctions underscore the importance of considering it as a variable in future research. Additionally, it highlights the need to explore the biological implications of alkali-releasable mediators.
Authors
- Kamil Borkowski (ORCID: https://orcid.org/0000-0003-3637-3450)
- Sitong Zhou (ORCID: https://orcid.org/0000-0002-1819-4144)
- Lee‐Way Jin (ORCID: https://orcid.org/0000-0001-9729-1032)
- Nuanyi Liang (ORCID: https://orcid.org/0000-0002-6802-5015)
- Geidy E. Serrano (ORCID: https://orcid.org/0000-0002-9527-2011)
- Izumi Maezawa (ORCID: https://orcid.org/0000-0002-8666-3520)
- John W. Newman (ORCID: https://orcid.org/0000-0001-9632-6571)
- Thomas G. Beach
- Kyoungmi Kim (ORCID: https://orcid.org/0000-0002-8661-7508)
- Bruce D. Hammock
Institutions
- United States Department of Agriculture (US)
- Banner Sun Health Research Institute (US)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086467
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00