Biological pathway‐based Alzheimer’s Disease polygenic risk score and proteinopathy
The biological pathway-based AD PRSs were associated with only Aβ/Tau pathway related latent proteinopathy score. We will explore PRSs for other diseases that are potentially related to AD etiology including Parkinson's disease linked to α-synuclein pathology, amyotrophic lateral sclerosis (ASL) with TDP-43 aggregation, cardiovascular diseases, cardiovascular risk factors, and psychiatric diseases.
Authors
- Kathryn Gauthreaux
- Peter T. Nelson (ORCID: https://orcid.org/0000-0002-6161-1265)
- Yuriko Katsumata (ORCID: https://orcid.org/0000-0002-0188-8094)
- Lincoln M. P. Shade (ORCID: https://orcid.org/0000-0001-6093-4823)
- Shama D. Karanth (ORCID: https://orcid.org/0000-0001-5371-6908)
- Erin L. Abner (ORCID: https://orcid.org/0000-0002-9566-4111)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Charles Mock (ORCID: https://orcid.org/0000-0002-0564-568X)
- Inori Tsuchiya
- Khine Zin Aung (ORCID: https://orcid.org/0009-0000-3793-6927)
- David W. Fardo (ORCID: https://orcid.org/0000-0002-7207-4696)
- Xian Wu (ORCID: https://orcid.org/0000-0003-1118-9710)
Institutions
- University of Kentucky (US)
- University of Washington (US)
- University of Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091359
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00