Antagonism between Hyperphosphorylated Tau and Heme Oxygenase‐1 in Alzheimer’s Disease
Hyperphosphorylated tau likely physically sequesters HO-1 as part of the mechanisms of tau pathology. Upregulating HO-1 confers cellular resistance to hyperphosphorylated tau. Our observations can help the design of reagents targeting the interface between p-tau and HO-1. Such reagents may have therapeutic potentials for Alzheimer's disease and other tauopathies.
Authors
- Min‐Hao Kuo (ORCID: https://orcid.org/0000-0001-8096-5344)
- Hsiao‐Tien Chien Hagar
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090017
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00