Multi‐Ethnic Analysis of Expression Quantitative Trait Loci (eQTL) in Alzheimer’s Disease: A Focus on Health Disparity Populations
Our study highlights the impact the AD disease process has on genetic variants that alter whole-blood gene expression. We also highlight differences by population, prompting the development of ethnically diverse gene expression panels that pave the way for more accurate genetic studies in health disparity populations. Our findings also underscore the potential for discovering novel genetic mechanisms influencing AD risk, which could lead to more effective and inclusive therapeutic strategies.
Authors
- Mario Cornejo‐Olivas (ORCID: https://orcid.org/0000-0001-6313-5680)
- Concepcion Silva
- Tianjie Gu
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Patrice L. Whitehead
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Nicholas R. Wheeler (ORCID: https://orcid.org/0000-0003-2248-8919)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Jóse Javier Sánchez (ORCID: https://orcid.org/0000-0002-6638-177X)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Makaela Mews (ORCID: https://orcid.org/0009-0006-6416-7581)
- Margaret A. Pericak‐Vance
- Larry D. Adams
- Lissette Gomez
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093307
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00