Polygenic scores for Alzheimer’s disease risk and resilience predict age at onset of amyloid‐β
PGS based on genetic risk and resilience for AD are both significant predictors of the age at which people are estimated to cross the threshold for high brain Aβ burden. Predicting the age at which a person will pass this threshold would enable treatment at an earlier stage, when it may more effectively delay or prevent symptom onset.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- James D. Doecke (ORCID: https://orcid.org/0000-0003-2863-0293)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Pierrick Bourgeat (ORCID: https://orcid.org/0000-0002-2605-4766)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Eleanor K. O’Brien (ORCID: https://orcid.org/0000-0001-5145-7340)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Timothy Cox (ORCID: https://orcid.org/0000-0002-7232-5096)
- Shane Fernandez (ORCID: https://orcid.org/0000-0002-4881-245X)
- Tenielle Porter (ORCID: https://orcid.org/0000-0002-7887-6622)
- Simon M. Laws (ORCID: https://orcid.org/0000-0002-4355-7082)
- Benjamin Goudey (ORCID: https://orcid.org/0000-0002-2318-985X)
- Christopher C. Rowe
Institutions
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Curtin University (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Australian e-Health Research Centre (AU)
- Austin Health (AU)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090024
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00