Identification of USP16 cryo‐EM protein structure and development of a small molecule inhibitor to restore compromised neural stem cell regeneration in a mouse Alzheimer’s model
Cryo-EM was successful in generating a course model of USP16. In silico protein modeling and drug screening was able to identify potential ligands against the ZnF domain of USP16.
Authors
- William Hai Dang Ho (ORCID: https://orcid.org/0000-0003-1365-9624)
- Daniel Fernández (ORCID: https://orcid.org/0000-0002-6221-152X)
- Felicia Reinitz (ORCID: https://orcid.org/0000-0003-4952-4457)
- Dalong Qian (ORCID: https://orcid.org/0000-0002-6261-5188)
- Angera H. Kuo (ORCID: https://orcid.org/0000-0001-6955-9951)
- Vincent M. Alford (ORCID: https://orcid.org/0000-0001-7162-9955)
- Elizabeth Montabana
- Elizabeth Y. Chen
- Michael F. Clarke (ORCID: https://orcid.org/0000-0001-6889-4926)
- Sydney Gottlieb
- Sabra Djomehri (ORCID: https://orcid.org/0000-0003-3790-5949)
- Zhen Qi (ORCID: https://orcid.org/0000-0003-1822-6975)
- Bharti Singal
- Grace Chung
- Francie I. Igboabuchi
Institutions
- California Institute for Regenerative Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093300
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00