943 variants identified synthesizing chromatin conformation capture and quantitative trait loci with results from the Alzheimer’s Disease Variant Portal study
Our analyses showed that using diverse functional annotations enables the discovery of new target genes not found in one assay alone. The ADVP variant regulated genes (supported by both eQTLs and chromatin interactions) implicated known disease mechanisms.
Authors
- Pavel P. Kuksa (ORCID: https://orcid.org/0000-0003-2248-6403)
- Yuk Yee Leung (ORCID: https://orcid.org/0000-0002-3047-5440)
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Jeffrey Cifello (ORCID: https://orcid.org/0009-0000-6147-2026)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089276
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00