Expression of the APOE4 allele influences the systemic environment to alter hippocampal phenotypes
We find that APOE alleles differentially alter the systemic environment to confer changes in brain phenotypes. Ongoing experiments focus on investigating the protective impact of the APOE3 systemic environment on molecular processes within the APOE4 hippocampus, which may ultimately inform our understanding of increased AD risk in APOE4 subjects.
Authors
- Joseph M. Castellano (ORCID: https://orcid.org/0000-0002-8026-6292)
- Ana Catarina Ferreira (ORCID: https://orcid.org/0000-0003-3723-2086)
- Manav Kapoor (ORCID: https://orcid.org/0000-0001-6682-940X)
- B Hemmer (ORCID: https://orcid.org/0000-0003-0898-5142)
- Towfique Raj (ORCID: https://orcid.org/0000-0002-9355-5704)
- Sarah M. Philippi (ORCID: https://orcid.org/0000-0002-4206-7575)
- Kailash BP
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092692
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00