Effects of Mediterranean vs. Western Diets on the Cerebral Cortical Pre‐Synaptic Proteome in Nonhuman Primates
Together these observations demonstrate that diet composition drives temporal presynaptic protein composition, that transcription profiles strongly predict the presynaptic proteomic profile, and that presynaptic proteins are closely associated with peripheral metabolism, stress responsivity, and socioemotional behavior. These data demonstrate the impact of diet composition on brain molecular composition.
Authors
- Thanaphong Phongpreecha (ORCID: https://orcid.org/0000-0001-9245-6686)
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Amalia Perna (ORCID: https://orcid.org/0000-0001-5569-8512)
- Jacob D. Negrey (ORCID: https://orcid.org/0000-0001-7355-0319)
- Nima Aghaeepour (ORCID: https://orcid.org/0000-0002-6117-8764)
- Carol A. Shively (ORCID: https://orcid.org/0000-0002-1536-2288)
- Sayane Shome
- Brett M. Frye (ORCID: https://orcid.org/0000-0001-8818-063X)
- Eloïse Berson (ORCID: https://orcid.org/0000-0003-1046-125X)
- Thomas J. Montine (ORCID: https://orcid.org/0000-0002-1346-2728)
- Thomas C. Register (ORCID: https://orcid.org/0000-0002-4078-0166)
- Geetha Clarke
Institutions
- Palo Alto University (US)
- Wake Forest University (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089274
- Primary Topic
- Machine Learning in Bioinformatics
- Type
- article
- Field-Weighted Citation Impact
- 0.00