Utilizing Latent Dirichlet Allocation and Differential Abundance to Identify Microbial Communities in both the Oral and Fecal Microbiome Associated with Alzheimer’s Disease

Our study has identified a variety of bacteria that exhibit novel community patterns that associate with AD. In the gut, A. gerencseriae and other oral microbiomes were observed in AD patients. Also, the microbial communities differ between AD and HC. Thereforth, we conclude that translocation of oral and gut microbiota may contribute to AD through an oral-gut-microbiome axis.