Relationship between cortical diffusivity and neuropathological substrates in Alzheimer’s disease

Our results suggest that cortical MD is an early marker of neuronal damage as it is observed simultaneously as Aβ deposition and as it is correlated with cortical thickness when there is no Aβ deposition. This suggests that cortical MD provides information about early microstructural changes before macrostructural changes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.093309
Primary Topic
Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Relationship between cortical diffusivity and neuropathological substrates in Alzheimer’s disease

Paul Edison, Justine Debatisse, Fangda Leng
Alzheimer s & Dementia
Neurological Disorders and Treatments
article

Relationship between cortical diffusivity and neuropathological substrates in Alzheimer’s disease

Paul Edison, Justine Debatisse, Fangda Leng
article en

Abstract

Our results suggest that cortical MD is an early marker of neuronal damage as it is observed simultaneously as Aβ deposition and as it is correlated with cortical thickness when there is no Aβ deposition. This suggests that cortical MD provides information about early microstructural changes before macrostructural changes.

Alzheimer s & DementiaVol. 20(S1)
Imperial College London (GB)
Openalex Percentile: Top 72%
Neurological Disorders and Treatments
DOIOpen Access PDFOpenAlex
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Relationship between cortical diffusivity and neuropathological substrates in Alzheimer’s disease — Paul Edison, Justine Debatisse, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS