Targeting Aging‐Related Neuroinflammation and Autophagy as Interventions for Late Onset Alzheimer’s Disease
LOAD+HFD mice model genetic x aging x environmental risk of sporadic late-onset AD and provide a more translationally relevant model to study potential benefits of interventions that target the mTOR pathway. These studies are poised to inform influence of AMPK on autophagy and inflammation to attenuate disease progression in LOAD; which may be better predictive of effects on sporadic AD than previous studies in young transgenic early-onset models of brain amyloid overexpression.
Authors
- Sean-Paul G. Williams (ORCID: https://orcid.org/0000-0002-5680-7730)
- Diogo Francisco da Silva dos Santos (ORCID: https://orcid.org/0000-0003-3306-2147)
- Toren Finkel (ORCID: https://orcid.org/0000-0002-0726-3546)
- John Willis (ORCID: https://orcid.org/0000-0002-7725-7432)
- Sangho Choi (ORCID: https://orcid.org/0009-0006-9106-7818)
- Afonso C. Silva (ORCID: https://orcid.org/0000-0002-6105-7567)
- Sara K. Quinney (ORCID: https://orcid.org/0000-0002-6554-0695)
- Nicholas S. Heaton (ORCID: https://orcid.org/0000-0002-5307-3428)
- Lais Da Silva (ORCID: https://orcid.org/0000-0003-3649-3292)
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Delfim Santos (ORCID: https://orcid.org/0000-0002-3710-4407)
- Katy A Haynes
- Bill B. Chen (ORCID: https://orcid.org/0000-0003-2695-5107)
- Leila Letica
- Lauren R Dubberley
- Yuan Liu (ORCID: https://orcid.org/0000-0001-5031-7514)
- Aman Reddy
- David J. Schaeffer (ORCID: https://orcid.org/0000-0003-2201-7092)
- Jason T Hart
- Umesh Nepali
Institutions
- University of Pittsburgh (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091053
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00