Pupil dilation during visual search is sensitive to plasma pTau181 levels in cognitively healthy older adults
Results suggest early functional changes in the LC noradrenergic system are detectable in biomarker-positive cognitively healthy older adults. Pupillary responsivity under task-induced conjunction search conditions may serve as a particularly sensitive marker of preclinical AD.
Authors
- Jingjing Zou (ORCID: https://orcid.org/0000-0002-4749-105X)
- Elena K. Festa (ORCID: https://orcid.org/0000-0002-3700-4270)
- Diane M. Jacobs (ORCID: https://orcid.org/0000-0003-0886-6784)
- William C. Heindel (ORCID: https://orcid.org/0000-0001-8258-5206)
- Camille A. Marangi (ORCID: https://orcid.org/0000-0002-1813-3122)
- Douglas R Galasko (ORCID: https://orcid.org/0000-0001-6195-3241)
- David P. Salmon (ORCID: https://orcid.org/0000-0003-4533-4090)
Institutions
- Brown University (US)
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092633
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00