Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and <i>MAPT</i> Sub‐haplotypes
This study identified that the copy number of γ was associated with the risk of PSP. H1 haplotypes with more γ duplication showed a higher odds ratio and were associated with MAPT sub-haplotypes with increased risk of PSP. These findings expand our understanding of how the complex structure of H1/H2 affect the risk of PSP.
Authors
- Wan‐Ping Lee (ORCID: https://orcid.org/0000-0002-5305-1181)
- Weixin Wang (ORCID: https://orcid.org/0000-0002-2765-2629)
- Timothy S. Chang (ORCID: https://orcid.org/0000-0002-9225-9874)
- Jung‐Ying Tzeng (ORCID: https://orcid.org/0000-0002-5505-1775)
- Daniel H. Geschwind (ORCID: https://orcid.org/0000-0003-2896-3450)
- Albert Tucci (ORCID: https://orcid.org/0000-0001-5703-7208)
- Beth A. Dombroski (ORCID: https://orcid.org/0000-0002-5334-1306)
- Po‐Liang Cheng (ORCID: https://orcid.org/0009-0007-0046-0313)
- Yaqin Si (ORCID: https://orcid.org/0000-0002-9968-9754)
- Hui Wang (ORCID: https://orcid.org/0000-0003-4043-5060)
- Gerald D. Schellenberg
Institutions
- North Carolina State University (US)
- University of California, Los Angeles (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086923
- Citations
- 1
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.23