Mild inhibition of mitochondrial complex I improves glucose metabolism and energy homeostasis in a cellular model of Alzheimer’s disease
Data suggested that mild MCI inhibition activates multiple neuroprotective mechanisms improving cellular energy homeostasis and mitochondrial function in vivo and in vitro, representing promising strategy that target early AD mechanisms.
Authors
- Eugenia Trushina (ORCID: https://orcid.org/0000-0002-6291-2860)
- Mark Ostroot (ORCID: https://orcid.org/0009-0009-1253-2120)
- Thi Kim Oanh Nguyen (ORCID: https://orcid.org/0000-0002-6068-6222)
- Sergey A. Trushin
Institutions
- Mayo Clinic (US)
- WinnMed (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085373
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00