Genetic variation of the Alzheimer’s disease risk gene CD33 modifies microglial immunometabolism
Together, these results provide insight on microglia-specific metabolic changes due to variations in the AD-associated risk gene CD33. This novel link between genetic, immune, and metabolic risk factors in AD has the potential to reveal new therapeutic and immunomodulatory strategies with which to reduce susceptibility to this neurodegenerative disease.
Authors
- Kirstin A. Tamucci (ORCID: https://orcid.org/0000-0002-7033-807X)
Institutions
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088368
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00