Amyloid, iron and cerebrovasculopathy in a new mouse model combining hemochromatosis mutations and Alzheimer’s amyloidosis and the etiological and diagnostic implications for dementia subtypes

Co-deposition of iron and Aβ within blood vessels is exacerbated by hemochromatosis-related mutations and can cause severe cerebrovasculopathy and amyloid angiopathy. This could lead to neuronal hypoperfusion and dysfunction throughout the brain in early disease stages and ultimately to neurodegeneraion. This has potential implications for understanding the etiology of dementia related to hemochromatosis mutations and for the clinical diagnosis of dementia subtypes.