White matter hyperintensities and Alzheimer’s disease susceptibility: a genome‐wide interaction study
Genomic variants moderate relationships between WMH and ATN biomarkers suggesting a novel regulatory role for a long non-coding RNA, and the involvement of microRNA MIR4300HG. This interaction study may help identify the contribution of specific genes and the potential pathways involved in the relationships between WMH and AD biomarkers.
Authors
- Ekaterina A. Rogaeva (ORCID: https://orcid.org/0000-0002-2852-0329)
- Aparna Bhan
- Arun Seth (ORCID: https://orcid.org/0000-0002-5715-8736)
- Saira Saeed Mirza (ORCID: https://orcid.org/0000-0002-0973-2246)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Meghan J. Chenoweth (ORCID: https://orcid.org/0000-0002-8218-8240)
- Katherine Zukotynski (ORCID: https://orcid.org/0000-0003-0584-4387)
- Shiropa Noor
- Yutaka Amemiya (ORCID: https://orcid.org/0000-0002-8057-6709)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Chris Heyn (ORCID: https://orcid.org/0000-0002-3226-5199)
- Che‐Yuan Wu (ORCID: https://orcid.org/0000-0001-8548-1824)
- Walter Swardfager (ORCID: https://orcid.org/0000-0002-0030-8908)
- Lisa Y. Xiong (ORCID: https://orcid.org/0000-0002-6342-9336)
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Demetrios J. Sahlas (ORCID: https://orcid.org/0000-0002-7986-3305)
- Daniel K Mori‐Fegan (ORCID: https://orcid.org/0000-0003-1290-7710)
- Christopher J.M. Scott (ORCID: https://orcid.org/0000-0002-3236-7523)
- Fuqiang Gao (ORCID: https://orcid.org/0009-0005-2239-4084)
- Yuen Yan Wong (ORCID: https://orcid.org/0000-0002-9567-5304)
- Mario Masellis
- Richard H. Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
Institutions
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- Heart and Stroke Foundation (CA)
- Toronto Rehabilitation Institute (CA)
- Health Sciences Centre (CA)
- Toronto Dementia Research Alliance (CA)
- Occupational Cancer Research Centre (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- McMaster University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.084982
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00