Vitamin A and Histone Deacetylases in Alzheimer’s disease: The Good, the bad and the ugly
Doses of vorinostat used in vitro and in vivo increased histone acetylation without cytotoxicity/toxicity. In vivo, we established that 125 mg/kg/week in diet is an optimal tolerable dose. VA, alone and in combination with vorinostat, may exhibit synergistic effects in protecting neuronal cells from oxidative stress. Together, our study provides a possible link between oxidative stress, Nrf2 and HDACs as potential contributors to Alzheimer's disease progression.
Authors
- Shane Smith (ORCID: https://orcid.org/0000-0003-4101-8234)
- Andy Baker (ORCID: https://orcid.org/0000-0002-1552-6166)
- Sharda P. Singh (ORCID: https://orcid.org/0000-0003-4361-4558)
- J. Josh Lawrence (ORCID: https://orcid.org/0000-0001-6416-984X)
- J. R. Strickland (ORCID: https://orcid.org/0000-0003-0845-8529)
- Iris P Guzmán Guzmán (ORCID: https://orcid.org/0000-0002-4804-0621)
- Chhanda Bose (ORCID: https://orcid.org/0000-0002-2121-4214)
- Ashly Hindle
Institutions
- Texas Tech University (US)
- Lubbock Christian University (US)
- Institute on Aging (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093281
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00