Single‐cell spatial transcriptomic and proteomic characterization of a novel mouse model of late‐onset AD
These exciting preliminary findings establish MAD1 as a novel platform model for testing various interventions in AD research, including demyelination. Future studies will explore the effects of aging, diet, remyelination, and other factors on MAD1 mice to elucidate the mechanisms of LOAD.
Authors
- Nellie Kwang (ORCID: https://orcid.org/0000-0001-8890-4976)
- Vivek Swarup (ORCID: https://orcid.org/0000-0003-3762-2746)
- Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086723
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00