Peripheral metabolism informs on future cognitive decline and development of Alzheimer’s disease in population at risk
Peripheral inflammation was linked to future cognitive decline and brain structural atrophy for population at risk. In addition, peripheral metabolomics-CSF proteomics correlation reveals distinguishing peripheral-central connection patterns in AD patients as well as MCI participant soon to develop AD in 3 years. Findings here point to peripheral systemic inflammation and metabolic health in general as risk factors in AD development, pointing to therapeutic intervention related to periphery metabolic health for patients at risk.
Authors
- Peter J. Meikle (ORCID: https://orcid.org/0000-0002-2593-4665)
- Kamil Borkowski (ORCID: https://orcid.org/0000-0003-3637-3450)
- Rima F Kaddurah-Daouk (ORCID: https://orcid.org/0000-0003-1858-5732)
- Nuanyi Liang (ORCID: https://orcid.org/0000-0002-6802-5015)
- Kevin Huynh (ORCID: https://orcid.org/0000-0001-6170-2207)
- Matthias Arnold (ORCID: https://orcid.org/0000-0002-4666-0923)
- John W. Newman (ORCID: https://orcid.org/0000-0001-9632-6571)
- Kwangsik Nho
Institutions
- United States Department of Agriculture (US)
- Baker Heart and Diabetes Institute (AU)
- Duke University (US)
- La Trobe University (AU)
- Helmholtz Zentrum München (DE)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089802
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00