Repeated reactivation of HSV‐1 in mouse brain spreads radially from the trigeminal ganglion, altering expression of synaptic and immune genes in patterns similar to early AD
Our HSV-1 reactivation mouse model identifies changes in gene expression that are similar to those observed in humans and mouse AD models, with observed, distinct changes in synaptic- and immune-associated genes in multiple brain regions. Activation of immune genes was highest in the brain stem, where detection of HSV-1 was highest. The greatest changes in gene expression occurred at 7 months, with fewer changes following at 10 months. These changes are most similar to changes in early disease and support the role of HSV-1 contributing to AD pathophysiology.
Authors
- Caitlyn Schaffer
- Christian Battaglia
- Jesse C. Wiley (ORCID: https://orcid.org/0000-0002-1430-772X)
- Martin Darvas (ORCID: https://orcid.org/0000-0002-7942-2526)
- Martine Aubert (ORCID: https://orcid.org/0000-0003-1125-6856)
- Christine Johnston (ORCID: https://orcid.org/0000-0002-3073-0843)
- Cory C. Funk (ORCID: https://orcid.org/0000-0002-5229-9011)
- Max Robinson (ORCID: https://orcid.org/0000-0003-0878-114X)
Institutions
- Sage Bionetworks (US)
- University of Washington (US)
- Institute for Systems Biology (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093497
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00