Translational profiling identifies sex‐specific metabolic and epigenetic reprogramming of microglia in cerebral amyloidosis models with an antibiotic‐altered gut microbiome

Our studies provide first snapshot of dynamic translational state of microglia in cerebral Aβ-amyloidosis models with an altered gut-microbiome. Gut metabolites can support microglial metabolic plasticity to modulate immune responses and amyloid clearance in a sex-specific manner. Reprogramming of microglial metabolism could be a promising strategy for restoring their physiological functions in a manner that might halt the progression of AD.