Cell type‐specific signatures of resilience to cognitive decline in the presence of brain pathologies
Using a combination of categorical and continuous definitions of resilience, together with existing single-nucleus RNA-sequencing data on cortical tissue from >600 human donors, we uncovered cell-type compositional changes in microglia, neurons and oligodendrocytes that are associated with global and domain-specific cognitive resilience to amyloid, tau and alpha-synuclein proteinopathies.
Authors
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Tain Luquez
- Dhwani Sreenivas
Institutions
- Columbia University Irving Medical Center (US)
- Rush University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088929
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00