Relationships between Circulating Monocyte and Brain Transcriptional Profiles in Nonhuman Primates Consuming Mediterranean versus Western Like Diets
Circulating monocyte gene expression profiles correlated with temporal cortex transcript levels consistent with anti-inflammatory effects of the Mediterranean Diet relative to the Western Diet, suggesting that peripheral inflammation may promote neuroinflammation. Interventions including diet to target inflammation may have a role in prevention or treatment of systemic as well as neuro-inflammation and neuropathology.
Authors
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Jacob D. Negrey (ORCID: https://orcid.org/0000-0001-7355-0319)
- Corbin S.C. Johnson (ORCID: https://orcid.org/0000-0001-9616-5755)
- Kathleen S. Montine (ORCID: https://orcid.org/0000-0003-2110-8363)
- Carol A. Shively (ORCID: https://orcid.org/0000-0002-1536-2288)
- Noah Snyder‐Mackler (ORCID: https://orcid.org/0000-0003-3026-6160)
- Brett M. Frye (ORCID: https://orcid.org/0000-0001-8818-063X)
- Thomas C. Register (ORCID: https://orcid.org/0000-0002-4078-0166)
Institutions
- Emory and Henry College (US)
- University of Washington (US)
- Wake Forest University (US)
- Arizona State University (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093067
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.27