Serial Imaging of Murine Brain Capillary Pericyte Dynamics in Hyperglycemia
Our study demonstrates how live, serial two-photon imaging of the same fields of view of the mouse cortex can reveal dynamic capillary and pericyte morphological changes in response to a hyperglycemic environment. This experimental model system can be deployed to investigate how pericytes changes over time may link microvascular changes in T2D to those in AD. Future studies will include additional analysis time points, as well as studies in 5xFAD mice, a widely used model of AD.
Authors
- Ukpong B. Eyo (ORCID: https://orcid.org/0000-0002-1294-475X)
- Shayn M. Peirce (ORCID: https://orcid.org/0000-0001-5857-5606)
- Kareem El‐Ghazawi
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088208
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00