The population of high CTLA‐4 expressing with CD56 positive T cell is diminished in Alzheimer’s disease patients

CD56 (NCAM) positive T cells with high expression of CTLA-4 decreased in AD patients. CTLA-4 played important role in T cell priming brake, and competed B7 ligand with CD28 to suppress T cell activation. Decrease of CTLA-4 expression on CD56+ T cells indirectly promote the immune activation. Our research indicated immune imbalance in peripheral blood of AD patients. Changes of T cell subpopulations may be biomarkers of AD, and maintaining homeostasis of immunity may be potential treatment of AD in future.