Single‐nucleus multi‐ome profiling of epigenomic modifications and transcriptome characterization of heterogeneity in early and late‐stage Alzheimer’s disease

The single nucleus multi-ome data produced in this study represents a valuable asset for the AD research community. Compared to bulk ATAC-seq, our single-nucleus epigenomic data provides precise insights into active and repressive activities. The study illuminates crucial TFs and their roles in AD, offering insights into cell-specific and region-specific mechanisms in AD pathology. Experimental validation underscores the functional relevance of the targeted TF in AD, highlighting its potential medical significance.