Single‐nuclei transcriptomic identifies type‐specific neuronal cell vulnerability in Amnestic and Logopenic Variant Primary Progressive Aphasia Alzheimer’s disease
Our preliminary study identified a vulnerable population of excitatory neurons related to lvPPA. We are conducting validation studies using quantitative pathology to confirm these results. Furthermore, analysis of a higher number of cases is ongoing and will continue to inform on factors associated with neuronal vulnerability.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Felipe Luiz Pereira (ORCID: https://orcid.org/0000-0001-9326-2365)
- Song Hua Li
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Bernardino Ghetti (ORCID: https://orcid.org/0000-0002-1842-8019)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Kathy L. Newell (ORCID: https://orcid.org/0000-0002-1648-7357)
- Jessica E. Rexach (ORCID: https://orcid.org/0000-0002-4462-7249)
- Liara Rizzi (ORCID: https://orcid.org/0000-0001-9823-8647)
- Igor Araújo (ORCID: https://orcid.org/0000-0002-9226-7321)
- Alexander Soloviev (ORCID: https://orcid.org/0000-0001-6519-1547)
- Caroline Lew (ORCID: https://orcid.org/0000-0002-4734-3153)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
Institutions
- University of California, Los Angeles (US)
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- WinnMed (US)
- University Memory and Aging Center (US)
- Mayo Clinic in Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091703
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00