The P301L tau mutation alters extracellular vesicle biogenesis in astrocyte and contributes to astrocyte‐mediated tau pathology in a human iPSC‐derived model of tauopathies
Our findings suggest a potential alteration in EV biogenesis in P301L iAs, potentially contributing to astrocyte-mediated tau pathology. Future investigations will focus on understanding how AEVs contribute to tau propagation and accumulation.
Authors
- Tsuneya Ikezu (ORCID: https://orcid.org/0000-0002-3979-8596)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Yang You (ORCID: https://orcid.org/0000-0003-0574-7827)
- Zbigniew K. Wszołek (ORCID: https://orcid.org/0000-0001-5487-1053)
- Wenyan Lü
- Jarosław Sławek (ORCID: https://orcid.org/0000-0001-6816-0877)
- Stephen Mann (ORCID: https://orcid.org/0000-0003-3012-8964)
- Takahisa Kanekiyo (ORCID: https://orcid.org/0000-0001-6751-9374)
- Wayne W. Poon (ORCID: https://orcid.org/0000-0003-0625-3968)
- Seiko Ikezu (ORCID: https://orcid.org/0000-0001-9879-730X)
Institutions
- University of California, Irvine (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088991
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00