5xFAD/<i>Abi3<sup>S209F</sup></i> mice display distinct age‐dependent effects on amyloid beta pathology and microglia dynamics
Together, these results characterize the effects of the Abi3<sup>S209F</sup> missense mutation on 5xFAD-mediated pathology, specifically in Aβ plaque development, glial morphology, and synapses. Our data suggests that this mutation may affect microglia dynamics in an age-dependent manner and may result in dysfunctional microglia at later stages of disease.
Authors
- Sherilyn Collins
- Ángela Gómez-Arboledas (ORCID: https://orcid.org/0000-0001-9636-9512)
- Kai‐Xuan Shi
- Frank M. LaFerla (ORCID: https://orcid.org/0000-0003-2324-6911)
- Heidi Yahan Liang (ORCID: https://orcid.org/0000-0002-6190-9723)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)
- Narges Rezaie (ORCID: https://orcid.org/0000-0001-9326-9954)
- A Mortazavi (ORCID: https://orcid.org/0000-0002-4259-6362)
- Giedre Milinkeviciute (ORCID: https://orcid.org/0000-0003-2527-3892)
- Celia Da Cunha
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Claire A. Butler (ORCID: https://orcid.org/0000-0001-9320-8297)
- Katie O'Gara
- Adrian Mendoza‐Arvilla (ORCID: https://orcid.org/0000-0002-9076-1983)
- Annie Thach
- Shuling Wang
- Jonathan Neumann
- Amber Walker
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089879
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00