Interactome Analysis of Tau‐seed Isolated from AD Brains Suggests New Mechanism for Tau Aggregation and Spreading
This study sheds light on tau propagation mechanisms in AD by identifying novel tau-seed interactors. These interactors, particularly those involved in synaptic and mitochondrial pathways, offer promising targets for therapeutic interventions aimed at decreasing tau spread and potentially preventing neurodegeneration in tauopathies. The findings add to the growing evidence that targeting tau-seed interactors, like previously identified BSN, could represent a novel strategy for treating these debilitating conditions.
Authors
- Nur Jury (ORCID: https://orcid.org/0000-0002-1143-3595)
- Pablo Martínez (ORCID: https://orcid.org/0000-0003-3496-4652)
- Sayan Deb Dutta (ORCID: https://orcid.org/0000-0001-9397-3140)
- Yanwen You
- Javier Redding‐Ochoa (ORCID: https://orcid.org/0000-0002-0677-917X)
- Cristian A Lasagna Reeves
- Juan C. Troncoso (ORCID: https://orcid.org/0000-0001-9553-6673)
- Jean‐Christophe Rochet (ORCID: https://orcid.org/0000-0002-6484-1541)
- Henika Patel (ORCID: https://orcid.org/0000-0002-2654-4669)
- Amber L. Mosley (ORCID: https://orcid.org/0000-0001-5822-2894)
- Yuhao Min (ORCID: https://orcid.org/0000-0001-8775-8743)
- Xiaoqing Huang (ORCID: https://orcid.org/0000-0003-3219-4316)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Jie Zhang (ORCID: https://orcid.org/0009-0004-5173-9996)
Institutions
- Carlow University (US)
- Johns Hopkins University (US)
- Purdue University West Lafayette (US)
- Johns Hopkins Medicine (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091621
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00