Aβ re‐wires CSF1R‐induced MAPK pathway activation in MMC microglia
These findings show that different agonists of CSF1R can provoke distinct profiles of canonical and non-canonical MAPK pathway signaling in the presence of Aβ1-42. Understanding differences in agonist-specific microglial signaling in healthy and diseased microglia will be essential to designing microglial-targeted therapeutics for treatment of AD.
Authors
- Srikant Rangaraju (ORCID: https://orcid.org/0000-0003-2765-1500)
- Sara Bitarafan (ORCID: https://orcid.org/0000-0002-8571-2490)
- Levi Benjamin Wood (ORCID: https://orcid.org/0000-0002-4248-0888)
- Brendan Tobin (ORCID: https://orcid.org/0000-0003-1250-4356)
- Zachary C. Uhlig
- Owen S Armentrout
Institutions
- Georgia Institute of Technology (US)
- Yale University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092388
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00